Consequences of Amino Acid Deprivation in Combination Chemotherapy

Amino Acid Properties and Consequences of Substitutions

Consequences of sleep deprivation.

This paper presents the history of research and the results of recent studies on the effects of sleep deprivation in animals and humans. Humans can bear several days of continuous sleeplessness, experiencing deterioration in wellbeing and effectiveness; however, also a shorter reduction in the sleep time may lead to deteriorated functioning. Sleeplessness accounts for impaired perception, diffi...

Drug-induced amino acid deprivation as strategy for cancer therapy

Cancer is caused by uncontrollable growth of neoplastic cells, leading to invasion of adjacent and distant tissues resulting in death. Cancer cells have specific nutrient(s) auxotrophy and have a much higher nutrient demand compared to normal tissues. Therefore, different metabolic inhibitors or nutrient-depleting enzymes have been tested for their anti-cancer activities. We review recent avail...

Amino acid deprivation promotes intestinal homeostasis through autophagy

Macroautophagy (here below referred to as autophagy) is a fundamental gatekeeper of intracellular homeostasis. On the one hand, autophagy operates at baseline levels to dispose of damaged organelles and other potentially cytotoxic byproducts of normal cellular functions, hence preserving metabolic and redox fitness in physiological conditions [1]. On the other hand, the autophagic machinery is ...

The control of ribonucleic acid synthesis during amino acid deprivation in Escherichia coli.

The rate of RNA synthesis in a stringent strain of Escherichia coli was measured before and during amino acid deprivation. Upon amino acid deprivation the rate of RNA synthesis rapidly fell to 30% of the control rate and did not significantly change from that value upon prolonged starvation. The composition of RNA synthesized during amino acid deprivation was investigated by hybridization-compe...